Non-random positioning of chromosomes in human sperm nuclei
نویسندگان
چکیده
منابع مشابه
Non-random chromosome positioning in mammalian sperm nuclei, with migration of the sex chromosomes during late spermatogenesis.
Chromosomes are highly organized and compartmentalized in cell nuclei. The analysis of their position is a powerful way to monitor genome organization in different cell types and states. Evidence suggests that the organization of the genome could be functionally important for influencing different cellular and developmental processes, particularly at early stages of development (i.e. fertilizat...
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Genome rearrangement often produces chromosomes with two centromeres (dicentrics) that are inherently unstable because of bridge formation and breakage during cell division. However, mammalian dicentrics, and particularly those in humans, can be quite stable, usually because one centromere is functionally silenced. Molecular mechanisms of centromere inactivation are poorly understood since ther...
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ژورنال
عنوان ژورنال: Chromosome Research
سال: 2004
ISSN: 0967-3849
DOI: 10.1023/b:chro.0000013166.04629.97